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matlab-based tool for the simulation and evaluation of systems pharmacology models  (MathWorks Inc)


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    MathWorks Inc matlab-based tool for the simulation and evaluation of systems pharmacology models
    Matlab Based Tool For The Simulation And Evaluation Of Systems Pharmacology Models, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/matlab-based tool for the simulation and evaluation of systems pharmacology models/product/MathWorks Inc
    Average 90 stars, based on 1 article reviews
    matlab-based tool for the simulation and evaluation of systems pharmacology models - by Bioz Stars, 2026-04
    90/100 stars

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    The minimal physiologically‐based pharmacokinetic ( <t>mPBPK</t> ) models that are used in ATLAS mPBPK. ( a ) mPBPK model for small molecules. ( b ) mPBPK model for large molecules with no target binding. ( c ) mPBPK model for large molecules with target binding in plasma (interstitial fluid). ( d ) mPBPK model for large molecules with target binding in peripheral tissues. Parameters' names and typical values are shown in Table . EV, extravascular; IV, intravenous; PO, oral.
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    matlab-based tool for the evaluation and simulation of systems pharmacology models  (MathWorks Inc)
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    The minimal physiologically‐based pharmacokinetic ( <t>mPBPK</t> ) models that are used in ATLAS mPBPK. ( a ) mPBPK model for small molecules. ( b ) mPBPK model for large molecules with no target binding. ( c ) mPBPK model for large molecules with target binding in plasma (interstitial fluid). ( d ) mPBPK model for large molecules with target binding in peripheral tissues. Parameters' names and typical values are shown in Table . EV, extravascular; IV, intravenous; PO, oral.
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    The minimal physiologically‐based pharmacokinetic ( mPBPK ) models that are used in ATLAS mPBPK. ( a ) mPBPK model for small molecules. ( b ) mPBPK model for large molecules with no target binding. ( c ) mPBPK model for large molecules with target binding in plasma (interstitial fluid). ( d ) mPBPK model for large molecules with target binding in peripheral tissues. Parameters' names and typical values are shown in Table . EV, extravascular; IV, intravenous; PO, oral.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

    doi: 10.1002/psp4.12441

    Figure Lengend Snippet: The minimal physiologically‐based pharmacokinetic ( mPBPK ) models that are used in ATLAS mPBPK. ( a ) mPBPK model for small molecules. ( b ) mPBPK model for large molecules with no target binding. ( c ) mPBPK model for large molecules with target binding in plasma (interstitial fluid). ( d ) mPBPK model for large molecules with target binding in peripheral tissues. Parameters' names and typical values are shown in Table . EV, extravascular; IV, intravenous; PO, oral.

    Article Snippet: In this tutorial, we present a MATLAB‐based tool for the modeling and simulation of mPBPK models (ATLAS mPBPK).

    Techniques: Binding Assay, Clinical Proteomics

    Concordance of simulated ATLAS mPBPK small‐molecule model values based on pharmacokinetic data of beta‐lactams. Figure is not an output of ATLAS mPBPK but was constructed by processing ATLAS mPBPK simulation output using MATLAB.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

    doi: 10.1002/psp4.12441

    Figure Lengend Snippet: Concordance of simulated ATLAS mPBPK small‐molecule model values based on pharmacokinetic data of beta‐lactams. Figure is not an output of ATLAS mPBPK but was constructed by processing ATLAS mPBPK simulation output using MATLAB.

    Article Snippet: In this tutorial, we present a MATLAB‐based tool for the modeling and simulation of mPBPK models (ATLAS mPBPK).

    Techniques: Construct

    Demonstration of ATLAS mPBPK large‐molecule model based on PK data of Trastuzumab (target binding in peripheral tissues) and Mavrillimumab (target binding in plasma) for a range of doses. Figures are not an output of ATLAS mPBPK but were constructed by processing ATLAS mPBPK simulation output using MATLAB. c‐TMDD, Target mediated drug disposition in plasma (central); hr, hour; mPBPK, minimal physiologically‐based pharmacokinetic modeling; p‐TMDD, target‐mediated drug disposition in peripheral tissues.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

    doi: 10.1002/psp4.12441

    Figure Lengend Snippet: Demonstration of ATLAS mPBPK large‐molecule model based on PK data of Trastuzumab (target binding in peripheral tissues) and Mavrillimumab (target binding in plasma) for a range of doses. Figures are not an output of ATLAS mPBPK but were constructed by processing ATLAS mPBPK simulation output using MATLAB. c‐TMDD, Target mediated drug disposition in plasma (central); hr, hour; mPBPK, minimal physiologically‐based pharmacokinetic modeling; p‐TMDD, target‐mediated drug disposition in peripheral tissues.

    Article Snippet: In this tutorial, we present a MATLAB‐based tool for the modeling and simulation of mPBPK models (ATLAS mPBPK).

    Techniques: Binding Assay, Clinical Proteomics, Construct